Steroid dosage in cats

Prednisolone 5 mg tablets contain a potent steroid and are to be used under the direct supervision of a veterinarian. All precautions and contraindications for adrenocortical hormones must be observed. Warning signs of cortisone overdosage may not be present. In certain cases, where large doses are required, the patient must be closely observed for side effects such as polyuria and polydipsia. When side effects occur, it may be necessary to reduce the dosage or discontinue therapy. Continuous large doses of Prednisolone 5 mg tablets may result in some depression of adrenocortical function and may produce adrenal atrophy. If long-term therapy is to be terminated, gradual withdrawal is recommended. The possible action of Prednisolone 5 mg tablets in delaying healing should also be considered.


Figure 1. Mechanism of action of glucocorticoids: 1) Glucocorticoids (GCs) enter the cell and bind to glucocorticoid receptors (GRs) in the cytoplasm. 2) GR-associated chaperone proteins are released, and the GC-GR complex moves through the nuclear membrane into the nucleus. 3) The GC-GR complex binds to positive or negative glucocorticoid response elements (pGREs and nGREs) on genes in the DNA, leading to increased or decreased mRNA production, respectively. 4) A GC-GR complex also may interfere with the action of other transcription factors bound to DNA. (Adapted from reference 2.)
Glucocorticoids have effects on nearly every organ system in the body. They are most commonly used, however, for their beneficial effect on the activity of the immune system. Glucocorticoids mediate their effects through various mechanisms, the most important of which seems to be through modulation of gene transcription. Glucocorticoids, like thyroid hormones, can enter the nucleus and access the DNA. Certain genes in the DNA carry regions known as glucocorticoid response elements (GREs). Binding of GREs by a glucocorticoid can result in either an increase or decrease in gene transcription and subsequent protein production. 1,2 Glucocorticoids also can interfere with the ability of other factors that regulate gene transcription ( Figure 1 ). 2 Because glucocorticoids can induce the production of new proteins, the effects of these drugs, or biologic half-life, can persist beyond their pharmacokinetic half-life. 1,2

The discontinuation of prednisone dog treatments should be gradual and performed over several weeks, because if this procedure is not respected, the dog may be affected by hyperadrenocorticism (commonly known as Cushing's disease ) or even adrenal gland insufficiency. This is due to the fact that the cortisone will stimulate the adrenal gland and if the treatment is suddenly discontinued, the adrenal glands may either fail to produce the needed amounts of hormones or produce these hormones in excess. The adrenal glands have to get accustomed to not getting prednisone, by slowly reducing the amounts of prednisone the dog gets.

Hi Lindsey,
My Baby 14 year old Birman has been on the prednisone pills for 13 years. Just recently he got really ill and hasn’t bounced back. He has IBD. I knew early on it came with consequences down the line… and recently he developed anaemia. He had every test imaginable and it all came back clear – thankgod!. No diabetes, liver function – all normal, even Vet amazed.
He is impossible to give a pill too.. and Vet’s have acknowledged this too. We are considering giving him the shot as he is worse dealing with it now even more than the last decade. What did your vet say about pill vs injection ?. Would love to know your thoughts, Kind Regards Michelle “loving Mum of Naughty Niska who won’t take his pills”

Steroid dosage in cats

steroid dosage in cats

Hi Lindsey,
My Baby 14 year old Birman has been on the prednisone pills for 13 years. Just recently he got really ill and hasn’t bounced back. He has IBD. I knew early on it came with consequences down the line… and recently he developed anaemia. He had every test imaginable and it all came back clear – thankgod!. No diabetes, liver function – all normal, even Vet amazed.
He is impossible to give a pill too.. and Vet’s have acknowledged this too. We are considering giving him the shot as he is worse dealing with it now even more than the last decade. What did your vet say about pill vs injection ?. Would love to know your thoughts, Kind Regards Michelle “loving Mum of Naughty Niska who won’t take his pills”

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