Polymorphisms in this gene can affect inhaled corticosteroid response in patients with asthma

An important group of SNPs are those that corresponds to missense mutations causing amino acid change on protein level. Point mutation of particular residue can have different effect on protein function (from no effect to complete disruption its function). Usually, change in amino acids with similar size and physico-chemical properties (. substitution from leucine to valine) has mild effect, and opposite. Similarly, if SNP disrupts secondary structure elements (. substitution to proline in alpha helix region) such mutation usually may affect whole protein structure and function. Using those simple and many other machine learning derived rules a group of programs for the prediction of SNP effect was developed:

Polymorphisms in this gene can affect inhaled corticosteroid response in patients with asthma

polymorphisms in this gene can affect inhaled corticosteroid response in patients with asthma

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polymorphisms in this gene can affect inhaled corticosteroid response in patients with asthmapolymorphisms in this gene can affect inhaled corticosteroid response in patients with asthmapolymorphisms in this gene can affect inhaled corticosteroid response in patients with asthmapolymorphisms in this gene can affect inhaled corticosteroid response in patients with asthmapolymorphisms in this gene can affect inhaled corticosteroid response in patients with asthma

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