Improvements in adherence were not consistently translated into observable benefit for clinical outcomes in our pooled analyses. None of the intervention types showed clear benefit for our primary clinical outcomes - exacerbations requiring an oral corticosteroid (OCS) (evidence of very low to low quality) and asthma control (evidence of low to moderate quality); nor for our secondary outcomes - unscheduled visits (evidence of very low to moderate quality) and quality of life (evidence of low to moderate quality). However, some individual studies reported observed benefits for OCS and use of healthcare services. Most school or work absence data were skewed and were difficult to interpret (evidence of low quality, when graded), and most studies did not specifically measure or report adverse events.
Pulmicort (budesonide) can come in solution which for asthma is then inhaled by using a nebulizer machine to aerosolize the medication. Swallowed Pulmicort (budesonide) is combined with other components such as Splenda to create a slurry which is then swallowed. This Swallowed budesonide (Pulmicort) Slurry may be used for those who may have more difficuly with dry swallowing fluticasone from an MDI. For those who are on swallowed steroids it is recommended not to eat or drink anything for 30 minutes after taking this medication so that it can provide optimal coating of the esophagus. Furthermore, anyone on these medications should swish and spit or brush their teeth after each use to remove any residual steroids in the mouth where it may have unwanted side effects.
It seems strange, then, that allergic reactions to corticosteroids actually occur—especially since these medications are used to treat allergic reactions. While severe allergic reactions to corticosteroids are extremely rare, they do in fact occur. Most allergic reactions to corticosteroids are less severe, however, and result from the topical formulations—occurring in up to 6% of people. Allergic reactions to oral or injected formulations are rarer, occurring in less than 1% of people. Causes of allergic reactions to corticosteroids may be due to IgE antibodies , or as a result of delayed-type hypersensitivity reactions caused by T-cells (a type of white blood cell).