During the treatment period, Lupron Depot-PED suppressed gonadotropins and sex steroids to prepubertal levels. Suppression of peak stimulated LH concentrations to < mIU/mL was achieved in 96% of subjects by month 1. Five subjects required increased doses of study drug to achieve or retain LH suppression. The number and percentage of subjects with suppression of peak stimulated LH < mIU/mL and mean ± SD peak stimulated LH over time is shown in Table 4. The mean ± SD age at the start of treatment was 7 ± 2 years and the duration of treatment was 4 ± 2 years. Six months after the treatment period was finished, the mean peak stimulated LH was ± SD mIU/mL (n=30).
Chronic lameness will change the shape of the hoof capsule, since the lame limb is not weighted as much as its partner, making the capsule more upright, narrow, with a higher heel on the lame limb and more flattened on the sound one.  Hoof or horseshoe wear can indicate breakover and if the horse is dragging its toes. Change in shape of the hoof wall is also common in horses suffering from laminitis. "Founder rings," or thickened concentric rings in the hoof wall, indicate a past episode of laminitis. Concavity of the dorsal (front) surface of the hoof can indicate chronic laminitis. The sole may become convex if the coffin bone begins to push through the bottom of the hoof. 
Analysis of serum testosterone concentrations from 117 hypogonadal men in the 84-week clinical study of Aveed indicated that serum testosterone concentrations achieved were inversely correlated with the patient's body weight. In 60 patients with pretreatment body weight of ≥ 100 kg, the mean (±SD) serum testosterone average concentration was 426 ± 104 ng/dL. A higher serum testosterone average concentration (568 ± 139 ng/dL) was observed in 57 patients weighing 65 to 100 kg. A similar trend was also observed for maximum serum testosterone concentrations.